The extended complexity hypothesis

on, translation e horizontally . A. (1999) Proc. thesis. The underlying idea is that informational genes belong to large, complex systems of coevolving genes. Consequently, the likelihood of the successful horizontal transfer low. Here, this ode of ing to complex systems are relatively less likely to be under adaptive evolution. To evaluate this “extended complexity hypothesis”, 2,428 families and protein domains were analyzed. This analysis found that genes whose products are highly connected, esses and e evolution than other gene products. The extended complexity hypothesis suggests that both the mode and the rate of evolution of a protein are influenced by its gene ontology (localization, biological process and molecular function) and by its connectivity. To explain why informational genes (i.e., those involved in transcripti and related processes) are less likely than housekeeping genes to b transferred, Jain and coworkers [Jain, R., Rivera, M. C. & Lake, J Natl. Acad. Sci. USA 96:3801-3806] proposed the complexity hypo of a single gene from such an integrated system is expected to be hypothesis is extended to explain some of the determinants of the m evolution of coding sequences. It is proposed that genes belong located in intracellular components, and involved in complex proc functions were more conserved and less likely to be under adaptiv at Penylvania State U niersity on Feruary 8, 2013 hp://m be.oxfournals.org/ D ow nladed from